-
Assessment Of Micronutrients In Children With Malaria Infection
CHAPTER ONE -- [Total Page(s) 3]
Page 3 of 3
-
-
-
1.3 Aim of Study
The
aim of this study is to assess the levels of micronutrients in children
with malaria infection in Paediatric Ward, Central Hospital, Benin
city.
1.4 Specific Objective
1. To evaluate the levels of vitamin B¬¬12,folic acid, iron, magnesium, and calcium in malaria infected children.
2. To correlate the micronutrient levels with the severity of malaria infection.
3. and to compare the results with the control group (non-infected children).
1.5 Research Design
This
is a case study designed to assess micronutrients status of malaria
infected children and then compare findings with non-infected children
in Benin City.
1.6 Ethical consideration
Ethical approval was sought and approved by the ethical committee of Central Hospital, Benin City, Edo State.
1.7 Research Hypothesis
H1:malaria parasites affects calcium, magnesium, iron ,vitamin B12,folic acid in children infected with malaria.
H0 malaria parasites does not affect calcium, magnesium, iron ,vitamin B12,folic acid in children infected with malaria.
1.8 Questionnaire/informed consent
A
questionnaire, written in English was administered to the parents of
the subjects to fill. An informed consent was given to the parents or
guardian of the children before sample was collected.
1.9 Sample size
The sample size (N) was calculated using prevalence from previous studies
The sample (Olasehinde et al., 2010). size for this study will be obtained using the formula described by Dean et al., (1995).
N = Z2P (1 – P)
D2
N = required sample size
Z = confidence level at 95% (standard value of 1.96)
P = estimated prevalence of intestinal parasites of pupils (84.7%)
D = margin of error at 5% (standard value = 0.05)
N=1.962 X 0.847(1-0.847)
0.052
3.8416 X 0.847(0.153)
___________________
0.0025
N=199 minimum sample sizes
Therefore
a minimum of 200 test samples and 100 control will be used for this
research.(Asaolu and Igbaakin, 2009). Vitamin B12 is involved in the
maturation of red blood cells. The folic acid coenzymes are specifically
concerned with metabolic reactions involving the transfer and
utilization of the one carbon moiety (Crook, 2012). Micronutrients
are found in small quantities within the body and they are obtained from
a wide variety of foods. No single food contains all of the
micronutrients we need and, therefore, a balanced and varied diet is
necessary for an adequate intake. Micronutrients deficiency is more
frequent amongst children in developing countries (Gibson and Ferguson,
1998). These deficiencies may contribute to an increased risk of
parasitic infection such as malaria (Mahomed, 2000).
CHAPTER ONE -- [Total Page(s) 3]
Page 3 of 3
-
-
ABSRACT - [ Total Page(s): 1 ]The increased clinical state of malaria infection may be due to poor nutritional status most especially as a result of micronutrients deficiency. Micronutrients play vital role both in combating anaemia and other adverse effects of malaria infection in humans and animals in developing resistance against the disease. This research was aimed at establishing the effect of malaria parasite on neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and some essential plasma electrolytes (calcium, magn ... Continue reading---
