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EVALUATION OF THE ACUTE CARDIOVASCULAR EFFECTS OF CHLOROQUINE MATERIAL
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ABSRACT - [ Total Page(s): 1 ]Cardiovascular effects of chloroquine following intravenous (iv) administration of chloroquine were investigated by administering chloroquine alone or in combination with other, drugs, (carbachol, acctychroline and atropine). The animals were cannulated. Blood pressure and heart rate were pleasured following intravenous administration through the femoral vein of different doses of either chloroquine and or acetyl-chroline, carbachol and Atropine. The results were(1) Chloroquine decreased the cat mean arterial blood pressure significantly and to a less extend the heart rate after the administra
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CHAPTER ONE - [ Total Page(s): 1 ]HISTORY: chloroquine is the most widely prescribed antimalarial agent (WHO 1984). It was synthesised during world war II due to the shortage of quinine and also for the need to produced less toxic and more effective antimalarial drug. In 1945 it was found out that chloroquine had been synthesised and studied under the name RESOCHIN as early asds 1934 in Western Germany (Catchpool 1984). Chloroquine has been used for many decades in the prophylactic and treatment of malarial (Bruce-Chwalt 1982, Rollo 1980) and for the treatment of thematoid disease (Costae 1970).CHEMISTRY: Chloroquine is a 4-am ... Continue Reading
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ABSRACT - [ Total Page(s): 1 ]Cardiovascular effects of chloroquine following intravenous (iv) administration of chloroquine were investigated by administering chloroquine alone or in combination with other, drugs, (carbachol, acctychroline and atropine). The animals were cannulated. Blood pressure and heart rate were pleasured following intravenous administration through the femoral vein of different doses of either chloroquine and or acetyl-chroline, carbachol and Atropine. The results were(1) Chloroquine decreased the cat mean arterial blood pressure significantly and to a less extend the heart rate after the administra
... Continue Reading
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